We are witnessing an explosion of knowledge about signal transduction pathways, impacting virtually all areas of biology and medicine. In order to be useful to the research community, this information must be synthesized and integrated into understandable paradigms of cellular communication. The following revised and updated diagrams have been assembled by Cell Signaling Technology (CST) scientists and outside experts to provide succinct and current overviews of selected signaling pathways. If you would like to suggest developing new pathway diagrams, please write info@cellsignal.com and a CST scientist will contact you shortly.

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Searchable Pathways Online

Chromatin Regulation / Acetylation
  • Protein Acetylation
  • Histone Methylation
Mitogen-Activated Protein Kinase Cascades
  • Mitogen-Activated Protein Kinase Cascades
  • MAPK/Erk in Growth and Differentiation
  • G-Protein-Coupled Receptors Signaling to MAPK/Erk
  • SAPK/JNK Signaling Cascades
  • p38 MAPK Signaling Pathways
Apoptosis / Autophagy
  • Overview: Regulation of Apoptosis
  • Inhibition of Apoptosis
  • Death Receptor Signaling
  • Mitochondrial Control of Apoptosis
  • Autophagy Signaling
PI3K/ Akt Signaling     
  • PI3K / Akt Signaling
Translational Control
  • Regulation of eIF4E and p70 S6 Kinase
  • Regulation of eIF2
  • mTor Signaling
Ca, cAMP & Lipid Signaling
  • Protein Kinase C Signaling
  • Phospholipase Signaling
Cell Cycle and Checkpoint Control
  • G1/S Checkpoint
  • G2M/DNA Damage Checkpoint

DNA Damage

Jak/Stat Pathway

  • IL-6 Receptor Signaling

NF-κB Signaling

  • NF-κB Signaling
  • Toll-Like Receptor Signaling

TGF-β Signaling

  • TGF-β Signaling

Neuroscience

Lymphocyte Signaling

  • B Cell Receptor Signaling
  • T Cell Receptor Signaling

Tyrosine Kinase/ Adaptors

  • Receptor & Cytoplasmic Tyrosine Kinases
  • ErbB / HER Signaling
  • Adaptor Proteins

Angiogenesis

  • Angiogenesis

Vesicle Trafficking

Cytoskeletal Signaling

  • Regulation of Microtubule Dynamics
  • Regulation of Actin Dynamics

Adhesion

  • Adherens Junction Dynamics

Embryonic Stem Cell and Lineage Markers

  • Embryonic Stem Cell and Lineage Markers

Glucose Metabolism

  • Insulin Receptor Signaling
  • AMPK Signaling

Wnt / Hedgehog / Notch

  • Wnt / β-Catenin Signaling
  • Hedgehog Signaling in Vertebrates
  • Notch Signaling

Nuclear Receptor

  • Nuclear Receptor

Protein Folding & Stability

Antibody Sampler Kits

Organelle Markers

Searchable Pathways

New England Biolabs web site. Nature's Services web site.